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Metformin (Glucophage): If Clomifene is not effective, metformin may help women with PCOS, especially when linked to insulin resistance. The Use of Epididymal Sperm in Assisted Reproduction. (PDF, 8 MB) Chapter from textbook, Frontiers in Endocrinology: Perspectives on Assisted Reproduction, 1994. Scrotal surgery, including vasectomy, hydrocelectomy (5-6%), and spermatocelectomy (up to 17%), may lead to epididymal injury and subsequent obstruction.[30] Antisperm antibodies Antisperm antibodies bind to sperm, impair motility, and lead to clumping, impairing movement through the female reproductive tract and interaction with the oocyte. Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 2 MB) Human Reproduction, 1996. MESA or TESA? (PDF, 115 KB) Human Reproduction, 1996. Effect of male age on fertility: evidence for the decline in male fertility with increasing age.

When this is not the case, a couple facing male infertility may turn to a sperm donor or adoption to help build their family. Fallopian tube factor: in vivo fertilisation takes place inside the fallopian tubes. Surgical sperm aspiration: The sperm is removed from part of the male reproductive tract, such as the vas deferens, testicle, or epididymis.

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Both infertility and subfertility are defined as the inability to conceive after a certain period of time (the length of which vary), so often the two terms overlap. At least one open tube is required for IUI, and the sperm abnormality cannot be severe otherwise the sperm will not be able to swim to and fertilize the egg. It is specially oriented for cancer patients, whose sperm is destroyed due to the gonadotoxic treatment they are submitted to.[70] Ovaric stem cells: it is thought that women have a finite number of follicles from the very beginning. Minimal Ovarian Stimulation (mini-IVF) for IVF Utilizing Vitrification and Cryopreserved Embryo Transfer. (PDF, 406 KB) Reproductive BioMedicine Online, 2010.

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These high-tech and expensive male infertility treatments give sperm an artificial boost to get into an egg. About 92 out of 100 couples who are trying to get pregnant do so within two years.[citation needed] Women become less fertile as they get older. Meticulous hemostasis is imperative. [131, 132, 133] Operative laparoscopy was reintroduced into the surgical armamentarium in the 1950s; however, in the 1970s, Semm developed different procedures and operative instruments that currently allow for the outpatient laparoscopic surgical treatment of multiple tuboperitoneal pathologies, [91] electrocautery, endocoagulation, lasers, and ultrasonography scalpels facilitate the performance of operations that otherwise used to require a laparotomy.

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Endometriosis is usually more common in women in their mid-twenties and older, especially when postponed childbirth has taken place.[55] Another major cause of infertility in women may be the inability to ovulate. In 10% of all cases, the cause is unknown: unexplained infertil Do you need help?  We can help you with a no-obligation Causes of infertility and sterility in women Diseases of the ovary and the uterus: Endometriosis is the reason behind many sterility issues. Microsurgical Epididymal Sperm Aspiration and Assisted Reproductive Techniques. (PDF, 4 MB) Frontiers in Human Reproduction, 1991. The main symptom of infertility is not getting pregnant.