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The mature spermatid is then located adjacent to the tubule lumen and contains dark chromatin with an oval-shaped nucleus. Modifiable and non-modifiable risk factors for poor semen quality: a case-referent study. A defect in any of these sperm structures may result in infertility that will not be detected by semen analysis.[60] Antisperm antibodies cause immune infertility.[23][24] Cystic fibrosis can lead to infertility in men.

Blood work to check hormone levels, usually of FSH and testosterone, but sometimes also LH, estradiol, or prolactin. Ongoing Pregnancies and Birth after Intracytoplasmic Sperm Injection with Frozen-thawed Epididymal Spermatozoa. (PDF, 442 KB) Human Reproduction, 1995. Thankfully, even when the cause of infertility is not known, various fertility treatments can overcome the unknown road block that was preventing pregnancy and eventually lead to delivery of a healthy baby.

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The use of Epididymal and Testicular Sperm for ICSI. (PDF, 1 MB) From IX World Congress on In Vitro Fertilization and Alternated Assisted Reproduction, 1995. It also shows if there are any abnormalities in the uterine cavity, such as polyps or submucous fibroids; or abnormalities of the tubes, such as evidence of salpingitis. After ruling out female infertility concerns, tests for male infertility may be needed. ARTICLES FROM THE 1990s Microsurgery, Andrology, and Its Role in IVF. (PDF, 6 MB) Chapter in text book, Advances in Assisted Reproductive Technology, 1990.

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Chemotherapy: Some types may significantly reduce sperm count. Thyroid problems: An overactive or underactive thyroid gland can lead to a hormonal imbalance.

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Dealing with Fertility Problems After Vasectomy Reversal. (PDF, 7 MB) Contemporary OB/GYN, 1978. Antibodies that are bound to sperm decrease the sperm’s ability to penetrate the cervical mucus and bind to the zona pellucida. Nevertheless, scientists have found these stem cells, which may generate new oocites in postnatal conditions. Oligospermia is the most frequent cause of male infertility. Chromosomal defects Hereditary disorders, such as Klinefelter’s syndrome (when a male is born with two X chromosomes and one Y chromosome instead of one X and one Y) impacts the normal development of the male reproductive organs. Practice Committee of American Society for Reproductive Medicine in collaboration with Society for Reproductive Endocrinology and Infertility. Compensatory and Obligatory Renal Growth in Rats. (PDF, 1 MB) American Journal of Physiology, 1974. Environmental vs Genetic Sex Determination: A Possible Factor in Dinosaur Extinction? (PDF, 307 KB) Fertility and Sterility, 2004. Demographic definitions of infertility An inability of those of reproductive age (15-49 years) to become or remain pregnant within five years of exposure to pregnancy. (DHS2) An inability to become pregnant with a live birth, within five years of exposure based upon a consistent union status, lack of contraceptive use, non-lactating and maintaining a desire for a child. (Trends in prevalence4).