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Men who are underweight tend to have lower sperm concentrations than those who are at a normal BMI. If a severe sperm defect is discovered, the testing on the female partner should be modified, and therapy can be immediately directed to the sperm problem. Luteinized unruptured follicle syndrome can be prevented by the administration of hCG (10,000 IU IM) once the follicle reaches 23-24 mm in diameter. However, some have suggested that patients should avoid conception for 6 months to 2 years after completion of radiation therapy because of the possibility of chromosomal aberrations in their sperm caused by the mutagenic properties of radiation therapy. Ongoing Pregnancies and Birth after Intracytoplasmic Sperm Injection with Frozen-thawed Epididymal Spermatozoa. (PDF, 442 KB) Human Reproduction, 1995.

Unexplained Even after a full fertility work-up, for one in five couples an exact cause of infertility cannot be determined. If the woman is over the age of 35 years old, she may be infertile if she has not become pregnant after 6 months of trying. Predominantly anovulation is caused by hormonal imbalances such as Polycystic Ovarian Syndrome (PCOS) but ovarian scarring and premature menopause can also result in failure to ovulate. • Tubal disease, comprising anything from mild adhesions to complete blockage of the fallopian tubes, prevents fertilised eggs from travelling from the site of fertilisation to the uterus. Semen is the milky fluid that a man's penis releases during orgasm. There are three main types of sperm antibodies: Immunoglobulin G (IgG) Immunoglobulin A (IgA) Immunoglobulin M(IgM). As the amount of adipose tissue increases, there is more aromatase available to convert androgens, and serum estradiol levels increase.

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ED may be the consequence of the conversion of androgens to estradiol. Prolactin stimulates milk production during breastfeeding. Torsion: Is a common problem affecting fertility that is caused by a supportive tissue abnormality which allows the testes to twist inside the scrotum which is characterized by extreme swelling.  Torsion pinches the blood vessels that feed the testes shut which causes testicular damage.  If emergency surgery is not performed to untwist the testes, torsion can seriously impair fertility and cause permanent infertility if both testes twist. PDF Articles by Decade: 1970s | 1980s | 1990s | 2000s | 2010s ARTICLES FROM THE 1970s Active Lupus Glomerulitis and Hematoxylin Bodies with Normal Urinalysis. (PDF, 5 MB) The Journal of Urology, 1971.

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Povey AC, Clyma JA, McNamee R, et al.; Participating Centres of Chaps-UK. Metabolic causes of infertility, other than in severely ill individuals, are rare. Close Testing for Women Women should track their ovulation by recording their basal body temperature for several months, checking their cervical mucus using a home ovulation test kit. The Treatment of Azoospermia with Surgery and ICSI. (PDF, 4 MB) Chapter 10 from Male Fertility & Infertility, 1998.

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Cushing disease Increased cortisol levels cause a negative feedback on the hypothalamus, decreasing GnRH release. Smoking: Smoking significantly increases the risk of infertility in both men and women, and it may undermine the effects of fertility treatment. Algorithm for infertility evaluation. (ART = assisted reproductive technology.) Infertility Evaluation Figure 1. Cabergoline is associated with fewer side effects but is more expensive. Treatment of the cause: 27. Tubal and uterine factors: 1. Hypospadias affects about 1 in every 500 newborn boys. While it may be difficult to detect infertility symptoms outright, here are some signs that may point to fertility issues: Irregular periods: The average woman’s cycle is about 28 days long. Enzymatic Digestion of Testicular Tissue May Rescue the Intracytoplasmic Sperm Injection Cycle in Some Patients with Non-obstructive Azoospermia. (PDF, 66 KB) Human Reproduction, 1998. Several methods are available to detect antisperm antibodies, such as radioimmunoassay and enzyme-linked immunosorbent assay, but the most specific test is the immunobead test. 2012;27(8):2396–2404.   Want to use this article elsewhere? Thus women whose pregnancy spontaneously miscarries, or whose pregnancy results in a still born child, without ever having had a live birth would present with primarily infertility. (Trends in prevalence4). Symptoms If a couple doesn't get pregnant after a year of unprotected intercourse, both the man and woman should be evaluated.