Infertility
Infertility Clinic Preston Hospital
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Successful Pregnancy after Microsurgical Transplantation of an Intact Ovary. (PDF, 438 KB) The New England Journal of Medicine, 2008. Around one third of couples have difficulty conceiving due to a low sperm count. In order to maximize the patient’s chances for successful fertilization, physicians typically use ovarian stimulation medications rather than using the single egg normally developed each cycle. Ovary Transplantation for Fertility Preservation in Cancer Patients: Fresh and Frozen. (PDF, 1 MB) Chapter 42 from textbook Clinial Infertility, 2010. In-vitro fertilization (IVF): Sperm are placed with unfertilized eggs in a petri dish, where fertilization can take place.
To ascertain a more precise assessment, a hysteroscopy of the uterus is run. Conventional In-vitro Fertilization vs Intracytoplasmic Sperm Injection for Patients Requiring Microsurgical Sperm Aspiration. (PDF, 3 MB) Human Reproduction, 1994. In the past, if the above methods didn’t work, it often meant lifelong male infertility. Factors Affecting Fertility: Timing of Intercourse Intercourse prior to ovulation is key to maximizing the chance of pregnancy. This mucus mainly affects the lungs, but males may also have a missing or obstructed vas deferens.
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Microsurgery Successful in Vasectomy Reversals. (PDF, 156 KB) The New York Times, 1975. If natural selection is the primary error correction mechanism that prevents random mutations on the Y chromosome, then fertility treatments for men with abnormal sperm (in particular ICSI) only defer the underlying problem to the next male generation.
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The most commonly prescribed pill to stimulate ovulation (generally of one mature egg) is clomiphene citrate. Some diseases: Conditions that are sometimes linked to lower fertility in males are anemia, Cushing's syndrome, diabetes, and thyroid disease. A high serum estradiol level (greater than 60 to 80 pg per mL [220 to 294 pmol per L]) in conjunction with a normal FSH level has also been associated with lower pregnancy rates. The chance of a live birth following treatment is nearly 50% [25]. Regression of Metastases after Nephrectomy for Renal Cell Carcinoma. (PDF, 1 MB) British Journal of Urology, 1975.
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Radiation therapy: This can impair sperm production. Chemotherapy: Some chemotherapy drugs can result in ovarian failure. The rate increases to 10-12% after CC ovulation induction and to 12-15% per cycle after hMG/hCG ovulation induction. Semen and sperm Sometimes the sperm cannot travel effectively to meet the egg. Recombination Between Palindromes P5 and P1 on the HUman Y Chromosome Causes Massive Deletions and Spermatogenic Failure. (PDF, 786 KB) The American Journal of Human Genetics, 2002. 40 Patients using these agents should be counseled about these risks. Seminoma Discovered in Two Males Undergoing Successful Testicular Sperm Extraction for Intracytoplasmic Sperm Injection. (PDF, 807 KB) Human Reproduction, 1995.
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See also
Infertility Knowledge Questionnaire
Female Infertility Kit
Obesity and Infertility