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0.[44] Environmental factors Toxins such as glues, volatile organic solvents or silicones, physical agents, chemical dusts, and pesticides.[45][46] Tobacco smokers are 60% more likely to be infertile than non-smokers.[47] German scientists have reported that a virus called adeno-associated virus might have a role in male infertility,[48] though it is otherwise not harmful.[49] Other diseases such as chlamydia, and gonorrhea can also cause infertility, due to internal scarring (fallopian tube obstruction).[50][51][52] Alimentary habits[53] Obesity: The obesity epidemic has recently become is a serious issue, particularly in industrialized nations. Successful Pregnancy after Microsurgical Transplantation of an Intact Ovary. (PDF, 438 KB) The New England Journal of Medicine, 2008.

Microsurgical Reversal of Tubal Sterilization: Factors Affecting Pregnancy Rate, with Long-term Follow-up. (PDF, 2 MB) Obstetrics & Gynecology, 1984. Basal body temperatures are no longer considered a reliable indicator of ovulation, and are not recommended for evaluating ovulation. These may cause abortion, neonatal death, fetal resorption, and apparent infertility. Basic Work-up for Infertility It is very important to remember that infertility can occur as a result of one or more male or female factors.

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Often, in vitro fertilization (IVF) can reveal abnormalities in egg quality, sperm function, or embryo development that would not have been determined from standard testing. Compensatory and Obligatory Renal Growth in Rats. (PDF, 1 MB) American Journal of Physiology, 1974.

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Low sperm mobility (motility): The sperm cannot "swim" as well as they should to reach the egg. Programming of Ovarian Stimulation with Norethindrone Acetate in IVF/GIFT Cycles. (PDF, 2 MB) Human Reproduction, 1989. Microsurgery Successful in Vasectomy Reversals. (PDF, 156 KB) The New York Times, 1975. Couples may decide to go ahead regardless if the desire to become pregnant is very strong. Inhibin B levels have been reported to decrease with increasing weight, which results in decreased Sertoli cells and sperm production.

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Oei SG, Helmerhorst FM, Bloemenkamp KW, Hollants FA, Meerpoel DE, Keirse MJ. GIFT (gamete intrafallopian tube transfer) and ZIFT (zygote intrafallopian transfer).  Like IVF, these procedures involve retrieving an egg, combining it with sperm in a lab, and then transferring it back to your body. Many men with low sperm counts or abnormal semen are still fertile. Production of the First Offspring from Oocytes Derived from Fresh and Cryopreserved Pre-antral Follicles of Adult Mice. (PDF, 2 MB) Reproductive BioMedicine Online, 2007. Causes of Sterility in Men Image: “Colorized sperm sample under the light microscope” by Bobjgalindo. Hormonal analysis Around 3% of cases of male infertility are estimated to be due primarily to a hormonal cause. The Avon Longitudinal Study of Pregnancy and Childhood Study Team. Opinion: Microsurgical TESE and the Distribution of Spermatogenesis in Non-obstructive Azoospermia. (PDF, 5 MB)Human Reproduction, 2000.