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IVF was a major breakthrough because it allowed for successful pregnancies in women that were previous deemed permanently infertile, such as when the fallopian tubes are both markedly damaged. The authors of the new global standards said the revised definition gave every individual “the right to reproduce.” Until now, the WHO’s definition of infertility—which it classed as a disability—has been the failure to achieve pregnancy after 12 months or more of regular unprotected sex. Microsurgical Reversal of Tubal Sterilization: Factors Affecting Pregnancy Rate, with Long-term Follow-up. (PDF, 2 MB) Obstetrics & Gynecology, 1984.

In patients with nonobstructive azoospermia, retrograde ejaculation can be the etiologic factor. [107] The treatment consists of recovering sperm from a urine sample collected immediately after ejaculation. Common symptoms of infertility include the following. It is increasingly recognized that egg quality is of critical importance and women of advanced maternal age have eggs of reduced capacity for normal and successful fertilization. The resulting injuries can result in perforated organs and can also lead to peritonitis.[medical citation needed] There may be an increased risk of hypothermia and peritoneal trauma due to increased exposure to cold, dry gases during insufflation. Malformation of the eggs themselves may complicate conception. Epididymal Extravasation Following Vasectomy as a Cause for Failure of Vasectomy Reversal. (PDF, 22 MB)Fertility and Sterility, 1979.

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First Fallopian Tube-Ovary Transplant Carried Out. (PDF, 2 MB) Welcome Trends in Ob/Gyn, 1985. When clomiphene binds to estrogen receptors in the hypothalamus, it leads to an increase release of an important signaling hormone called GnRH (gonadotropin releasing hormone). 3) Insemination: Intrauterine insemination, also known as IUI, is a process by which sperm is washed and prepared for placement into the uterine cavity, therefore bypassing the cervix and bringing a higher concentration of motile sperm closer to the tubes and ovulated egg. These rates, of course, readjusted down for the older women with long durations of infertility [42]. Paternal age > or = 40 years: an important risk factor for infertility. Microsurgery and Andrology. (PDF, 5 MB) Chapter from textbook, 1991.

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They can also carry out some basic tests on both partners to see if there is an identifiable reason for not having achieved a pregnancy. 6 Women with risk factors for tubal obstruction, such as endometriosis, previous pelvic infections, or ectopic pregnancy, should instead be offered hysteroscopy or laparoscopy with dye to assess for other pelvic pathology. If this becomes a regular occurrence, it may interfere with sexual intercourse or be a sign of an underlying issue. No Differences in Outcome after Intracytoplasmic Sperm Injection with Fresh or with Frozen-thawed Epididymal Spermatozoa. (PDF, 66 KB) Human Reproduction, 1999. Once a follicle containing an egg reaches a mature size, another hormone injection called HCG is often given to mimic the natural LH surge that occurs at the time of ovulation.

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ART techniques generally start with stimulating the ovaries to increase egg production. Basal body temperatures are no longer considered a reliable indicator of ovulation, and are not recommended for evaluating ovulation. For example, 10 to 15 percent of untreated chlamydia cases will lead to pelvic inflammatory disease (PID). Young syndrome is a condition that leads to inspissation of material and subsequent blockage of the epididymis. The rate increases to 10-12% after CC ovulation induction and to 12-15% per cycle after hMG/hCG ovulation induction. Congenital Absence of the Vas Deferens: The Fertilizing Capacity of Human Epididymal Sperm. (PDF, 3 MB) New England Journal of Medicine, 1990. Vasectomy. (PDF, 5 MB) From the Encyclopedia of Reproduction, 1999. Normal fertility is observed in three fourths of patients with unilateral mumps orchitis and in one third of patients in bilateral orchitis. Article Sections Infertility is defined as the inability to achieve pregnancy after one year of regular, unprotected intercourse. Povey AC, Clyma JA, McNamee R, et al.; Participating Centres of Chaps-UK. Cryptorchidism may be due to inherent defects in both testes because even men with unilateral cryptorchidism have lower than expected sperm counts. The progestins that can be used and the doses are as follows: Medroxyprogesterone acetate (eg, Depo-SubQ Provera 104; administer 104 mg SC q3mo or q12-14wk) Megestrol acetate (eg, Megace 20-40 mg PO qd for up to 2 months) Norethindrone acetate (eg, Aygestin 15 mg PO qd for 6-9 months) [145, 146, 147, 148, 149, 150] The androgens used are 17-ethinyl testosterone derivatives (eg, danazol 400-800 mg PO divided BID; not to exceed 9 months) [151, 152, 153] The GnRH agonists used are as follows: Leuprolide acetate (eg, Lupron 3.