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Post-testicular causes of infertility Post-testicular causes of infertility include problems with sperm transportation through the ductal system, either congenital or acquired. Success rates reported by various practices that offer ICSI range from 15% to 30% per egg retrieval. Analyses of the CFTR Gene in 67 Patients. (PDF, 4 MB) The American Journal of Human Genetics, 1995. Microsurgical Solutions to Male Infertility. (PDF, 2 MB) Contemporary OB/GYN, 2005.

Calcification of the Seminal Vesicles and Vas Deferens in a Uremic Patient. (PDF, 3 MB) The Journal of Urology, 1971. 8,45 Figure 1 provides an algorithmic approach to the evaluation of infertility.   Enlarge      Print Infertility Evaluation Figure 1.

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Abnormal semen may not be able to carry the sperm effectively. Alcohol: Any amount of alcohol consumption can affect the chances of conceiving. A needle biopsy of the testicle can show whether a man is making healthy sperm. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. 6 Accuracy may be improved by use on midday or evening urine specimens, which correlate better with the peak in serum luteinizing hormone levels. Testing for Men In the case of men, a general physical examination will be performed, with discussions concerning medical history, illnesses, disabilities, medications and sexual habits.

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Spermatid Conception. (PDF, 1 MB) Human Reproduction, 1998. Transmission of Male Infertility to Future Generations: Lessons from the Y Chromosome. (PDF, 303 KB) Human Reproduction Update, 2002. Down syndrome These patients have mild testicular dysfunction with varying degrees of reduction in germ cell number. Microsurgical Solutions to Male Infertility. (PDF, 2 MB) Contemporary OB/GYN, 2005.

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2 This encompasses couples with infertility and impaired ability to get pregnant, but it does not capture those who are not married, so actual numbers may be underestimated. You made this process easier by being supportive and positive. Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis.(PDF, 958 KB) Reproductive BioMedicine Online, 2010. The chance of a multiple birth is lower with an oral fertility drug. It can either be used to inspect and diagnose certain conditions or to surgically correct an abnormality such as removing scar tissue, endometriosis, or a damaged fallopian tube. In one study,  treatment with recombinant HBD1 in asthenozoospermic and leukocytospermic patients who were deficient in HBD1 resulted in improved bactericidal activity and sperm quality, which supports this protein’s role in fertility and its potential role in managing infertility.[28] Other causes Causes of testicular failure also include the following: Granulomatous disease – Leprosy and sarcoidosis may infiltrate the testicle Sickle cell disease – Sickling of cells within the testis leads to microinfarcts Excessive use of alcohol, cigarettes, caffeine, or marijuana Despite a thorough workup, nearly 25% of men have no discernible cause for their infertility. Nonchromosomal testicular failure Testicular failure that is nonchromosomal in origin may be idiopathic or acquired by gonadotoxic drugs, radiation, orchitis, trauma, or torsion. The pathophysiology of the disease is not well understood, but a massive extravascular accumulation of fluid occurs that is associated with a severe depletion of the intravascular volume responsible for dehydration, hemoconcentration, and electrolyte imbalance (ie, hyponatremia, hyperkalemia). [193] Ovarian hyperstimulation syndrome can be mild, moderate, or severe. [194] Mild ovarian hyperstimulation syndrome is characterized by ovarian enlargement (up to 5-12 cm in diameter), minimal ascites, and weight gain of less than 10 lb. Overweight or obesity: This may reduce the chance of conceiving. Success rates for induction of ovulation vary considerably and depend on the age of the woman, the type of medication used, the presence of other infertility factors present in the couple and other reasons. A varicocele is like a varicose vein that can appear in the leg. Women who have a body weight 10% to 15% below normal may have reduced fertility. High Fertilization and Pregnancy Rate after Intracytoplasmic Sperm Injection with Spermatozoa Obtained from Testicle Biopsy. (PDF, 3 MB) Human Reproduction, 1995. Sertoli Cell only Revisited. (PDF, 1 MB) Human Reproduction, 1995. Conventional IVF vs ICSI (Intra Cytoplasmic Sperm Injection) for Patients Requiring Microsurgical Epididymal Sperm Aspiration (MESA). (PDF, 4 MB) Chapter from textbook, Frontiers in Endocrinology: Perspectives on Assisted Reproduction, 1994.