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Common causes of infertility of females include: ovulation problems (e.g. polycystic ovarian syndrome, PCOS, the leading reason why women present to fertility clinics due to anovulatory infertility.[58]) tubal blockage pelvic inflammatory disease caused by infections like tuberculosis age-related factors uterine problems previous tubal ligation endometriosis advanced maternal age immune infertility Males[edit] The main cause of male infertility is low semen quality. The FAST study: fertility assessment and advice targeting lifestyle choices and behaviours: a pilot study. By the end of this step, most of healthcare professionals will be able to sketch out their provisional diagnosis. Unicornuate uterus is associated with renal abnormalities including absence of a kidney or presence of a pelvic kidney; this occurs in 15% of cases. ART: In Vitro Fertilization In Vitro Fertilization (IVF) is a procedure that involves retrieving eggs and sperm from the female and male partners and placing them together in a laboratory dish to enhance fertilization. These microdeletions are not observed on regular karyotype testing; rather, their identification requires polymerase chain reaction (PCR)–based sequence-tagged site mapping or Southern blot analysis.

CC is a nonsteroidal estrogen capable of interacting with estrogen receptor–binding proteins in a manner similar to estrogen but in a more prolonged way. [159, 160] Therefore, CC behaves similar to an antiestrogen. However, these tests have only poor to moderate predictive value despite widespread use.

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Metformin (Glucophage): If Clomifene is not effective, metformin may help women with PCOS, especially when linked to insulin resistance. Alcohol: Any amount of alcohol consumption can affect the chances of conceiving. Age: Male fertility starts to fall after 40 years. Pro-life opposition to the destruction of embryos not transferred in vivo.

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Uterine surgery: - Women with amenorrhoea who are found to have intrauterine adhesions should be offered hysteroscopic adhesiolysis because this is likely to restore menstruation and improve the chance of pregnancy. 29 When the semen analysis is abnormal, referral to a male fertility specialist or reproductive endocrinologist is warranted. Ovarian hyperstimulation syndrome The ovaries can swell, leak excess fluid into the body, and produce too many follicles, the small fluid sacs in which an egg develops. In some cases, the reproductive urologist can improve semen function by recommending certain lifestyle changes, by hormonal treatments, or by surgery. There are tests that may tell if you have fertility problems. Secondary fertility involves one or both partners who have conceived previously, but are now unable to do so because of a possible physical or medical condition impairing fertility.

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The production of anti-sperm antibodies by the woman’s immune system can interfere with fertilization. 8 Intrauterine insemination and ovulation induction do not result in increased pregnancy rates in women with unexplained infertility. Further investigations 18. Laparoscopy: - Invasive procedure. - to check for pelvic disease; such as endometriosis and to check tubal patency. - therapeutic as in laparoscpic myomectomy and ovarian drilling. Hysteroscopy: - to evaluate uterine cavity. - In case of repeated failed IVF cycles. - therapeutic as in intrauterine septum. Treatment of Uterine Factors Until in vitro fertilization became available, a patient with congenital absence of the uterus and vagina (Rokitansky-Küster-Hauser syndrome) had no chance to have a biologic child. ARTICLES FROM THE 2010s Ovarian Function 6 Years after Cryopreservation and Transplantation of Whole Sheep Ovaries. (PDF, 496 KB)Reproductive BioMedicine Online, 2010. The easiest and most successful treatment is intrauterine insemination (IUI). [104] Similar treatments apply when oligospermia, hypospermia, and ejaculatory disorders such as impotence, hypospadias, or retrograde ejaculation are present. [105, 106, 107] Patients with azoospermia that is not amenable to in vitro fertilization/intracytoplasmic sperm injection treatment benefit from artificial insemination (AI) with donor sperm. [108] Artificial insemination can be performed by depositing the sperm at the cervical level (cervical insemination) [106] or inside the endometrial cavity (intrauterine insemination). If the egg does not travel, it can be harder to conceive naturally. The treatment of uterine malformations depends on the severity of the problem. Pregnancy After Testicular Transplant: Importance of Treating the Couple. (PDF, 5 MB) Fertility and Sterility, 1980. An ultrasound scan can detect an ectopic pregnancy.