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Many of these treatment options may have harmful or unpleasant side effects such as nausea, headaches and weight gain. Prolonged estrus may be caused by ovarian cysts that produce estrogen, functional ovarian tumors, or exogenous estrogens (including human transdermal hormone replacement therapy). Hysteroscopy can also be combined with laparoscopy when necessary. Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 2 MB) Human Reproduction, 1996.

Congenital Absence of the Vas Deferens: The Fertilizing Capacity of Human Epididymal Sperm. (PDF, 3 MB) New England Journal of Medicine, 1990. For women, being underweight and having extremely low amounts of body fat are associated with ovarian dysfunction and infertility and they have a higher risk for preterm birth. Abnormal semen may not be able to carry the sperm effectively.

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If a woman has an ovulation disorder, she may ovulate infrequently or not all. Cryopreservation: Cryopreservation of semen, oocytes or embryos should be offered to anyone who may undergo treatment that may affect his/her fertility. (e.g.: chemotherapy for cancer). For cancer-related fertility preservation, do not apply the eligibility criteria used for conventional infertility treatment. Do not use a lower age limit for cryopreservation for fertility preservation in people diagnosed with cancer.

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Diverse Spermatogenic Defects in Humans Caused by Y Chromosome Deletions Encompassing a Novel RNA-binding Protein Gene. (PDF, 7 MB) Nature Genetics, 1995. Instructions for collecting the sample should include abstinence from ejaculation for 48 to 72 hours. Analyses of the CFTR Gene in 67 Patients. (PDF, 4 MB) The American Journal of Human Genetics, 1995.

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Intracytoplasmatic Sperm Injection (ICSI) An intracytoplasmatic sperm injection is also a form of artificial insemination. Most couples (about 84%) who have regular sexual intercourse (that is, every two to three days) and who do not use contraception get pregnant within a year. Also, polymorphisms in folate pathway genes could be one reason for fertility complications in some women with unexplained infertility.[62] However, a growing body of evidence suggests that epigenetic modifications in sperm may be partially responsible.[63][64] Diagnosis[edit] If both partners are young and healthy and have been trying to conceive for one year without success, a visit to a physician or women's health nurse practitioner (WHNP) could help to highlight potential medical problems earlier rather than later. 38,39 Family physicians may choose to attempt ovulation induction in anovulatory women (WHO group II) with clomiphene. Quantitative Analysis of Testicle Biopsy: Determination of Partial Obstruction and Prediction of Sperm Count after Surgery for Obstruction. (PDF, 4 MB) Fertility and Sterility, 1981.