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Histology reveals seminiferous tubules lined by Sertoli cells and a normal interstitium, although no germ cells are present. One of the best known is the HFEA – The UK's regulator for fertility treatment and embryo research. Although CASA produces good qualitative data, it is a labor-intensive procedure with a high initial cost and is plagued with inaccuracies when sperm concentrations are very high or very low.

Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and surgery, orchitis, varicocele, infections, prostatitis, testicular cancer, failure of immunosuppression and unprotected receptive anal or oral sex with men.[23][24] Sexually transmitted infections[edit] Infections with the following sexually transmitted pathogens have a negative effect on fertility: Chlamydia trachomatis and Neisseria gonorrhoeae. Men with this type of male infertility have normal sperm in the testicles. It is often prescribed for Crohn's disease or rheumatoid arthritis. This results in normal or enhanced follicular recruitment without the risk of multiple ovulation and ovarian hyperstimulation syndrome.

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Depending on the sperm count, the couple is advised to have intercourse near the time of ovulation or to proceed with intrauterine insemination. Intrauterine insemination 50% of women will conceive after 6 cycles. Half of the unsuccessful ones, will conceive with further 6 cycles. It is artificial introduction of semen inside the female’s uterus. Success rate varies, lie between 15% to 20% per cycle. The advent of computer chip-based television cameras was a seminal event in the field of laparoscopy. The incidence of congenital malformation in IVF babies ranges between 2% and 3% worldwide and is similar to that in babies conceived naturally [45].

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Females[edit] The following causes of infertility may only be found in females. Men with elevated prolactin levels present with gynecomastia, diminished libido, erectile dysfunction, and occasionally galactorrhea. Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort.

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By 2014, over 5 million people had been born after being conceived through IVF. If natural selection is the primary error correction mechanism that prevents random mutations on the Y chromosome, then fertility treatments for men with abnormal sperm (in particular ICSI) only defer the underlying problem to the next male generation. Polycystic ovary syndrome (also known as Stein-Leventhal syndrome) and hyperprolactinemia can also cause anovulatory cycles through hormonal imbalances.[1][2] Functional problem[edit] This accounts for around 10-15% of all cases of anovulation. Approximately 10% of cases are unexplained, where no definitive cause can be identified. Causes include: Surgery: Pelvic surgery can sometimes cause scarring or damage to the fallopian tubes. Many of the same surgeries performed in humans can be applied to animal cases – everything from an egg-bound tortoise to a German Shepherd can benefit from MIS. Malformation of the eggs themselves may complicate conception. Often, in vitro fertilization (IVF) can reveal abnormalities in egg quality, sperm function, or embryo development that would not have been determined from standard testing. Thankfully, even when the cause of infertility is not known, various fertility treatments can eventually lead to delivery of a healthy baby.