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Enzymatic Digestion of Testicular Tissue May Rescue the Intracytoplasmic Sperm Injection Cycle in Some Patients with Non-obstructive Azoospermia. (PDF, 66 KB) Human Reproduction, 1998. Debate: Are Spermatid Injections of any Clinical Value? (PDF, 6 MB) Human Reproduction, 1998. A sperm count of under 15 million is considered low. Fibroids that distort the uterine cavity have an impact on the ability of an embryo to implant and should be removed surgically.

Transplantation of a Human Testis for Anorchia. (PDF, 19 MB) Fertility and Sterility, 1978. In this condition, semen ejaculates backwards into the bladder instead of out the penis. Symptoms of hormone fluctuations Signs of hormone fluctuations in women could indicate potential issues with fertility. 2 This encompasses couples with infertility and impaired ability to get pregnant, but it does not capture those who are not married, so actual numbers may be underestimated.

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Some couples experience pressure from society, parents and family, who expect that they wish to have children. The basic work-up, or fertility evaluation, includes: Semen analysis of the male partner. The optimum fertile period is around 23 years of age when only 5% of women have issues getting pregnant. Opinion: Microsurgical TESE and the Distribution of Spermatogenesis in Non-obstructive Azoospermia. (PDF, 5 MB)Human Reproduction, 2000. Congenital disorders and chryptorchidism (undescended testicles). Aetiology of Congenital Absence of Vas Deferens: Genetic Study of Three Generations. (PDF, 4 MB) Human Reproduction, 1993.

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Causes Potential causes of male infertility are: The complete absence of sperm (azoospermia) Low sperm count (oligospermia) Abnormal sperm shape (teratozoospermia) Problems with sperm movement (asthenozoospermia) Sperm that is completely immobile (necrozoospermia); the sperm may be alive and not moving, or they may be dead Problems with sperm delivery, due to sexual dysfunction, an obstruction, previous vasectomy, or retrograde ejaculation Problems with erections or other sexual problems There are a variety of conditions that may lead to male infertility. In one study,  treatment with recombinant HBD1 in asthenozoospermic and leukocytospermic patients who were deficient in HBD1 resulted in improved bactericidal activity and sperm quality, which supports this protein’s role in fertility and its potential role in managing infertility.[28] Other causes Causes of testicular failure also include the following: Granulomatous disease – Leprosy and sarcoidosis may infiltrate the testicle Sickle cell disease – Sickling of cells within the testis leads to microinfarcts Excessive use of alcohol, cigarettes, caffeine, or marijuana Despite a thorough workup, nearly 25% of men have no discernible cause for their infertility. Sperm retrieval for azoospermia and intracytoplasmic sperm injection success rates – A personal overview. (PDF, 1 MB) Human Fertility, 2010.

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Overheated testicles: Causes include an undescended testicle, a varicocele, or varicose vein in the scrotum, the use of saunas or hot tubs, wearing tight clothes, and working in hot environments. Intercourse 2 or 3 times per week may be considered average, although the frequency varies. B.: No role for basal body temperature charts) Basic Work-up for Infertility 14. Ovarian reserve -More important in >35 years old, suspected ovarian failure and to detect response to ovulation induction. Source : Preserving your fertility - University of Kansas Hospital PPT Presentation Summary : Preserving your fertility. Smoking: Smoking significantly increases the risk of infertility in both men and women, and it may undermine the effects of fertility treatment. Benefits of laparoscopy are especially the possibility to simultaneously remove adhesions in one session. Sex any other time, even the next day after ovulation, will not result in conception. “We generally advise couples to seek fertility evaluations if they are unable to conceive after 12 months of unprotected intercourse,” says Lawrence Ross, MD, president of the American Urological Association. If each step has occurred as planned, implantation of the fertilized egg into the uterus can take place within 72 hours of the ICSI process. Surprisingly, most patients have normal libido, erections, and orgasms, so testosterone therapy has only a limited role; exogenous testosterone may also suppress any underlying sperm production. 10 Data Sources: A PubMed search was completed using the key terms infertility, subfertility, treatment, etiology, and diagnosis. Treatment of tubal obstruction generally requires referral for subspecialty care.